The second most common cannabinoid found in cannabis is CBD. Unlike psychoactive THC, CBD does not attach to the same binding sites on the CB1 or CB2 receptors. THC binds to orthosteric binding sites while CBD binds to allosteric binding sites on the same receptor. CBD opposes some actions of THC at the CB1 receptor, decreasing the psycho-activity, anxiety and tachycardia caused by THC.CBD has no psychoactive effects but has a number of medical applications, including relieving nausea, inflammation, and anxiety.CBD indirectly stimulates endogenous cannabinoid signaling by suppressing the enzyme fatty acid amidehydroxylase (FAAH). FAAH breaks down anandamid and CBD allows anandamide to remain for longer duration which enhances endocannabinoid tone by suppressing FAAH.CBD stimulates the release of 2-AG, an endocannabinoid that activates both CB1 & CB2 receptors.